Diagonal earlobe creases and fatal cardiovascular disease: a necropsy study.
" In addition to coronary artery disease, we found that those with other fatal
cardiovascular diseases such as ruptured aortic aneurysms also tended to
have earlobe creases. "
"The presence of a previous cardiovascular disease was not as strongly associated
with cardiovascular causes of death as the presence of an earlobe crease alone.
This suggests that cardiovascular disease was being underdiagnosed in the population. "
The earlobe crease, coronary artery disease, and sudden
cardiac death: an autopsy study of 520 individuals.
" ELC was strongly correlated with CAD in both men and women but with sudden cardiac death
(SCD) only in men.
The sensitivity of the ELC sign was 75% and the positive predictive value (ppv) was 68%. In individuals below 40 years, the ppv was as high as 80%. Using multiple logistic regression
analysis, ELC was found to be the strongest independent risk factor for CAD and SCD apart
from age and BMI (both genders), as well as baldness and hair in the meatus externa (in males). "
Increased all-cause and cardiac morbidity and mortality associated
with the diagonal earlobe crease: a prospective cohort study.
' ..... a diagonal ELC is associated with increased all-cause and cardiac morbidity and
mortality. Patients with ELCs may be at higher risk for coronary events, and might be
especially cautioned to control or reduce other cardiac risk factors, even if currently
without diagnostic evidence of CAD. "
Earlobe creases and coronary atherosclerosis. The view from forensic pathology.
" ..... 800 consecutive autopsies performed for medicolegal reasons and thus
including a wide spectrum of subjects.
Statistical analysis by the chi2 test demonstrated a positive correlation between
the presence of the diagonal earlobe crease and obstructive coronary atherosclerosis
narrowing on at least one major coronary artery greater than 75%. "
Diagonal ear lobe crease and coronary risk factors.
" Ear lobe biopsies in 12 subjects revealed tears of the elastic fibers in all subjects
with ELC, and prearteriole wall thickening in subjects with MI and/or ELC, but not
in the 2 subjects with neither MI nor ELC. The early appearance of ELC may imply
the existence of coronary heart disease with or without coronary risk factors. "
This Brazilian study is the only one on preauricular creases.
Association between coronary artery disease and the diagonal earlobe
and preauricular creases in men
" The bilateral presence of ELC (ear lobe creases) and PAC (preauricular creases)
was positively associated to CAD even after adjusting for other coronary risk variables.
The presence of both creases represented sensitivity of 56.3% and a positive
predictive value of 90%. "