Antioxidants Protect Against Brain Cancer
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Thread: Antioxidants Protect Against Brain Cancer

  1. #1
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    Antioxidants Protect Against Brain Cancer

    "Also, an inverse relationship between antioxidant
    levels and grades of malignancy has been found
    after histopathological examination of brain tumors. "

    " Moreover, high intake of vitamin E is correlated
    with greater survival for all patients diagnosed as
    Grade III malignant glioma. "

    " Dietary supplementation with antioxidants [e.g. vitamins
    C & E] was found to reduce the incidence of brain tumors
    in children whose mothers took these vitamins throughout
    pregnancy. "

    " On the other hand, decreases in antioxidant levels
    were correlated with the severity of malignancy of
    brain tumors .... "

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21434862




    " The most striking dietary finding was a significant
    protective effect among glioma pairs of use of vitamin
    supplements, which increased with increasing
    frequency of use (p for trend = 0.04; odds ratio for
    use at least twice a day = 0.4.) "

    http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=1855850

  2. #2
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    " For astrocytomas, which form a subtype of the gliomas, a
    elevated risk of 10.3 was found; a significant upward trend
    of tumor incidence with increasing length of employment
    was observed. Most astrocytoma patients who worked in
    occupations involving exposure to EM fields were electricians
    or electrical engineers. "

    http://www.ncbi.nlm.nih.gov/entrez/q...ids=%202012622

  3. #3
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    The Japanese hedge parsley, Torilis japonica,
    widespread weed.

    A Torilis japonica extract exerts anti-proliferative activities
    on the U87MG human glioblastoma cell line.

    (U87MG is an aggressive glioblastoma multiforme
    cell line used extensively in brain cancer research.)

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21472352


    http://www.efloras.org/florataxon.as...n_id=200015963

    http://plants.usda.gov/java/profile?symbol=TOJA

    http://www.naturalmedicinalherbs.net...ge-parsley.php

  4. #4
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    What leads to cancer where healthy cells turns maglinant?
    TASK - Trust, Attitude, Skill, Knowledge - Signatures of those who believe in excellence for any task entrusted to them - Alwin Tan @ all rights reserved
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  5. #5
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    Basically it's a genetic disease, either acquired, or
    mutated somewhere along those years from the
    cradle to the grave.

    Oncogenes triggered off by many factors - congenital,
    physiological, diet, environment, drugs, lifestyle, etc.

    There is a Hayflick limit inbuilt into our cells - they die
    after about 50 divisions.

    Cancer cells are such normal cells where the Hayflick limit
    has been turned off. As long as you feed them, they are immortal.

    In essence, it's a computer program gone haywire.

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    To the best of my understanding in simple layman term, cells becomes maglinant or goes haywire as the mutation due to oxidation process.
    Picture that ion exchange as in the iron rod - given time due to oxidation process i.e. moisture and salt, it turns rusty and erodes with time. But well protected with a coat of paint or oil that protect against erosion or prevent it with a plastic, would reduce or slow it down. Otherwise, when the ion exchange of the molecular structure would affected the other nearest part to go rusty or mutate until the iron may be brittle and break down.

    This analagy would be my explanation when it comes to where the cells in the body mutated and start to go haywired until it causes the failure of organs that keeps us alive. Therefore as in the case of breast cancer management, the surgeon would cut the affected part to prevent the disease from progressing with the mutated cells. However, in some cases, the disease keeps progressing to other breast or other areas as the immune system been compromised with the imprinted code of mutation or simply might have been weaken without the support of oxidation prevention,-i.e. antioxidant nutrients like vitamin E, beta carotene, lycopene or other factors like smoking and stress.

    However in the genetic, the task to avoid malignant cells is more difficult as the DNA may be encoded with in the cells. Chances of having cancer with those with the family histories of would be highly probable and extra effort is needed to prevent the cells to go haywire.

    Though without scientfic clinical studies done, many clinicals still attribute the mutation of cells like diet of modern susbtance in our food from coloring, preservatives to taste enhancers to be the excitotxin that stimualte cells to turn cancerous.

    Just like one clinician stated - it has been regarded as safe where you can cook food in a plastic that can withstand it without damage in the microwave. But why take the chance where you can cook it with the glassware where the structure would not change as the plastic ones. Cooking in the microwave with "approved" plastic doesnt means it would not harm you. So is storing food or water in the plastic bottles where variants of factors like bisphenol.

    Am I right in thinking like those clinicians?
    Last edited by zinglicious; 29-09-2011 at 07:05 AM.
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  7. #7
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    Free radicals, and oxidation, is only just one factor
    which may make the gene/cell mutate.

    Many other factors are involved - viruses, aging,
    mitochodrial dysfunction, failure of cancer suppressive
    genes - in particular p53.

    The growth, mulitplication and death of each of our cells
    are a fine balance between proapoptotic (cell death) genes (like p53,
    BAX, Fas) and antiapoptotic (cell survival) genes (like Bcl2, Bcl-x, ras).

    A disruption of this balance, such as when proapoptotic genes
    are defective or inactivated, and/or antiapoptotic genes are
    overactivated, will result in cancer.


    Defective apoptotic pathways

    " The many different types of apoptotic pathways contain a
    multitude of different biochemical components, many of them
    not yet understood.[35] As a pathway is more or less sequential
    in nature, it is a victim of causality; removing or modifying one
    component leads to an effect in another. In a living organism this
    can have disastrous effects, often in the form of disease or disorder.
    A discussion of every disease caused by modification of the various
    apoptotic pathways would be impractical, but the concept overlying
    each one is the same: the normal functioning of the pathway has
    been disrupted in such a way as to impair the ability of the cell to
    undergo normal apoptosis. This results in a cell that lives past its
    "use-by-date" and is able to replicate and pass on any faulty
    machinery to its progeny, increasing the likelihood of the cell becoming
    cancerous or diseased. "


    Dysregulation of p53

    " The tumor-suppressor protein p53 accumulates when DNA is damaged
    due to a chain of biochemical factors. Part of this pathway includes
    alpha-interferon and beta-interferon, which induce transcription of the
    p53 gene and result in the increase of p53 protein level and enhancement
    of cancer cell-apoptosis.[37] p53 prevents the cell from replicating by
    stopping the cell cycle at G1, or interphase, to give the cell time to repair,
    however it will induce apoptosis if damage is extensive and repair efforts
    fail. Any disruption to the regulation of the p53 or interferon genes will
    result in impaired apoptosis and the possible formation of tumors. "


    Inhibition of apoptosis

    " Inhibition of apoptosis can result in a number of cancers, autoimmune
    diseases, inflammatory diseases, and viral infections. It was originally
    believed that the associated accumulation of cells was due to an
    increase in cellular proliferation, but it is now known that it is also due
    to a decrease in cell death. The most common of these diseases is
    cancer, the disease of excessive cellular proliferation, which is oftentimes
    characterized by an overexpression of IAP family members. As a result,
    the malignant cells experience an abnormal response to apoptosis
    induction: cycle regulating genes (such as p53, ras or c-myc) are mutated
    or inactivated in diseased cells, and further genes (such as bcl-2) also
    modify their expression in tumors. "

    http://en.wikipedia.org/wiki/Apoptosis


    One such culprit which can trigger this off are viruses. Easily 20 per
    cent of cancers are in fact caused by viruses. One prime example
    is nasopharyngeal carcinoma (nose and throat cancer), caused
    by EBV, the Epstein-Barr virus, one of the herpes family.

    A virus can easily enter a gene, take out some of the gene's DNA
    and insert its own DNA, and the result is the gene becomes defective
    or overactive.

    Viruses are also implicated in brain cancers, in this case particularly
    cytomegalovirus, CMV. This is another of those pesky herpes viruses,
    known to cause several cancers, autoimmune and other diseases.

    CMV is most likely the culprit behind glioblastome multiforme, the
    most aggressive of brain tumors.

    http://www.thedailybeast.com/newswee...mor-virus.html

    http://www.wired.com/wiredscience/20...d-a-herpes-vi/

    http://www.nature.com/news/2008/0805....2008.855.html


    And cervical cancers in women are almost always caused
    by HPV, the human papilloma, or wart virus.

  8. #8
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    So, are the antioxidants supplements like Vitamin E indicated to treat these cancers as suggested in the thread ?
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  9. #9
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    If you read the studies carefully, antioxidants are
    more for prevention, but they also show that people
    with a high level of them tend to have less aggressive
    brain cancer, as well as longer survival, particularly
    with vitamin E.

    Thus taking them when you already have the cancer
    will also boost your chances of fighting the disease.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17998669

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=11341043


    However, because many chemotherapy drugs actually
    shrink the tumors by way of oxidation, it may not be
    advisable to take antioxidants during each course of
    chemotherapy. Better to wait at least two weeks after
    each cycle.


    If you wish to try vitamin E to fight cancer, take the "dry" form
    called alpha tocopherol succinate, which most research shows
    has far more powerful anticancer activity. The more common oily form,
    alpha tocoperol acetate, which you find in softgels in the pharmacies
    here, are not really effective.

    Tocopherol succinate can be found at most health food stores
    in the US :

    http://www.iherb.com/Vitamin-E-Dry


    Tocopherol succinate and brain cancer.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=16001965


    Tocopherol succinate and prostate cancer.

    http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=8584452


    The tocotrienols are also potent supplements. Quite expensive,
    if you look in the pharmacies here. Hovid makes them, extracted
    from palm oil. Gamma tocotrienol is especially promising.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435257

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21793834


    Pancreatic cancer.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21723941


    Leukemia.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21660856


    Breast cancer.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21516480

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21622228

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21429729


    Gamma tocotrienol and prostate cancer.

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21335085



    " Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E. "

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21505906


    " Tocotrienols fight cancer by targeting multiple cell signaling pathways. "

    http://www.ncbi.nlm.nih.gov/entrez/q..._uids=21484157
    Last edited by Tham; 30-09-2011 at 03:38 AM.

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    But was told that supplement diet causes more harm than good in studies done by JAMA! http://jama.ama-assn.org/content/297/8/842

    Antioxidants are widely used as ingredients in dietary supplements and have been investigated for the prevention of cancer. Although initial studies suggested that antioxidant supplements might promote health, later large clinical trials did not detect any benefit and suggested instead that excess supplementation is harmful. (Concerning the previous studies cited the first only shows that antioxidant supplements were not effective in helping against "mountain sickness", and in the second study showed that the supplements beta carotene, vitamin A , and vitamin E, "singly or combined, significantly increased mortality."
    Though it says that "Most trials investigated the effects of supplements administered at higher doses than those commonly found in a balanced diet" whereas it says "Vitamin C and selenium had no significant effect on mortality.")
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  11. #11
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    That is why you have to learn not to believe everything you
    read in the press or online. I ignore a lot of them.

    If you believe everything they say, you will end up just drinking
    plain water for the rest of your life, and end up living shorter.

    JAMA = published by American Medical Association = Interests
    in drug companies.

    Moreover, many of these trials are faulted due to bad design, or come
    out with conflicting results due to many other conflicting factors.

    You will find this is the case time and again when you use Medline.


    The recent large SELECT trial in prostate cancer was abandoned
    halfway because they used the wrong forms -

    1. Vitamin E as acetate

    2. Selenium as selenomethionine, ineffective compared to the inorganic
    forms, sodium selenite and selenate, when you want to fight cancer.

  12. #12
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    True, And if you have been following my thread - "Healthy with no MSG" you would find that the links I provided should be read withwide eyes on the fine print and open mind. ( whole thread deleted by the moderator because I was told that I was advertising my food which is unitentional due to forumers request without warning. Whole load of links downed the drain. )

    Anyway, I was a medical detailer from pharmaceutical firms in my young and handsome days and that is why I read with caution too. JAMA or FDA more or less the same if there is an vested interest especially with druugsa corporation. But as in the above studies, it is not fair to slam the JAMA article. - there are good responsible clinicians too.

    In fact, the clinicians are slamming the "Wellness" or Direct Sales Multi Vitamins which usually comprised of multi level marketing companies promoting thier A to Z .

    excess supplementation is harmful. (Concerning the previous studies cited the first only shows that antioxidant supplements were not effective in helping against "mountain sickness", and in the second study showed that the supplements beta carotene, vitamin A , and vitamin E, "singly or combined, significantly increased mortality." ( from above extraction )

    BTW, I used to ignore what my company send me with those piles of favorable clinical papers. Instead I used to compiled from the doctors where they get from my competitor companies. Hence I believe I had a good track record when I conduct lectures in the hospitals and the heads of dept readily assist me to set up one or many. In fact, Dato Suseela Nair - Malaysian notable breast surgeon and I pioneer the Breast self examination program where we used to conduct public lectures to the public in 1980's

    I dont know what is your purpose by indicating this studies is flawed because it is being cross references with thousands of patients and clearly there is no material gains from this report.

    Pray tell you are not from the multi nation multi vitamins suppplement agents trying to promote your drugs without giving the full picture.

    And if you can, kindly enlightened me why the above link from JAMA is flawed or misleading.http://jama.ama-assn.org/content/297/8/842.

    BTW, if you have read from my column. I hold a special interest in nutrition and cancer in memory of my beloved brother who died from colon cancer at 45. been with a world leading oncology corporation, invested in Nasdaq bio tech oncology counters and cooked in restaurant with no MSG.
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  13. #13
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    Common sense will tell you I am not a "supplement agent promoter",
    otherwise I would not just be citing the benefits of supplements IN GENERAL,
    like selenium and tocotrienols, rather than ...... " BUY AMWAY " !

    This thread was started because I happened to be posting the same
    in another forum on brain cancer and thought I'd post the same here
    for you people's benefit.

    (As I have experienced, I get accused of being biased or some
    "supplement advertiser" when posting something like this in layman's
    forums, so I was wary of wasting my time with this kind of topic,
    and not at all surprised when I received your kind of response.)

    I'm a life extensionist (people who follow cutting-edge supplement,
    as well as experimental drug, protocols in an attempt to prolong, or
    at least improve the quality, of life, as well as fight diseases, particularly
    those of aging), who comes from this forum.

    I'd suggest you take part too, if you wish to know more about life extension.


    The Immortality Institute, now called Longecity.

    http://www.longecity.org/forum/forum...cine-diseases/

    Most of my posts are in the Alzheimer's and "Cancer Knowledge" threads.


    You will also find a lot of cutting-edge discussion in the
    "Supplements", "Nootropics" and "Resveratrol" sections.

    http://www.longecity.org/forum/forum/6-supplements/

    http://www.longecity.org/forum/forum/169-nootropics/

    http://www.longecity.org/forum/forum/312-resveratrol/


    I used to take part in the Life Extension Foundation's forum,
    but their highly-informed moderator, Tom Matthews, left years ago.

    http://forum.lef.org/


    I developed an interest in this after buying two books way
    back in 1986 -

    "Mega Nutrition", by Richard Kunin

    "Ageless Ageing", by Leslie Kenton


    I found out about the Life Extension Foundation after borrowing
    the book "Life Extension: A Practical Scientic Approach" from
    the Memorial Library opposite Dataran Merdeka, sometime in 1995.


    The JAMA study is just a meta-analysis, which is basically a collection
    of the results of many trials over the years. I tend not to place much
    faith in such meta-analyses, but prefer to go over the trials individually.

    Cross-referencing from "thousand of patients" doesn't mean they
    are the gospel truth. That is why you have to use Medline with a
    grain of salt.


    It's good you are running a restaurant with no MSG. I used to buy
    Maggi mee's "No MSG" packets until they discontinued it.

  14. #14
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    Even then you are might taking the wrong meals especially as a life extension -as there is chemical elements in Maggi mee which is non nutritious to your health. Best take whatever natural to feed and nourish your body. That is part of food intake which is suppose to be instead of just satisfy our hunger pangs.
    Contrary to your view in many ways, I am more in preventive medicine rather than cutting edge micracle cure to prolong life.

    Hence, it always back to nature as possible. my motto is you are what you eat. Hence I even try to make it from Jama or BMA paper without those medical jargons to demonstrate my beliefs. And waht more with simple food and meals where it can preserve, provide , protect, prevent, !!!

    Yes I do keep in touch periodically what is happening in sciene or technology to prolong life in various angles. not that I believe in living old but I just have a curious mind.

    However I beg to disgree when you just shut down the value of thousand of patients. It is a good effort by the clinicians to produce the paper without vested interests. Moreover, no studies can be done to determine the subject throughout as it is quite impossible unless you are keeping the subjects throughout the life span. There are too many variables of diets, envioroments, and arguably it cannot be a controlled studies at all. More science of breakthrough drugs from prolonging life to placentas stiill would not be feasible scientific studies where it can cross check with placebo or double blind studies to determined efficacies of treatment which is the gold standard. Moreover, the number of patients in the controlled studies is very small to make a meaningful judgement.

    In short nothing is gospel truth from A to Z because of variance of change and factors. Just a gold standard - RIRO Rubbish in Rubbish out with cross referencing and randomized methods

    See, from the day I started posting in this forum - I use my shop name - Zinglicious. to post whatever I feel passionate about. And even my restaurant at Subang is closed down, I am still posting eagerly when I see a healthy thread. No hidden agenda, no artificial flavoring or color name
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  15. #15
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    That is why most people have the wrong concept of life extension.


    Not "using a miracle cure", but an "attempt" to extend life , or
    improve its quality in old age, with a comprehensive supplement
    regimen, technique and of course, lifestyle and diet.

    Those are the two basic tenets of life extension
    - Quantity, and/or
    - Quality


    The supplement regimen remains the most feasible and practical.
    Unless you (as a highly-stressed city dweller) manage to follow
    the diet and lifestyles of the Vilcabamban Indians, Hunzas, Georgians,
    Okinawans as well as the Bamas and Hetians in China, you MUST
    use a cutting-edge regimen of supplements/drugs to try to extend
    your lifespan, or improve its quality in old age.

    You can read my response to this member's thread here :

    http://www.longecity.org/forum/topic...ost__p__473390




    And when trying to treat diseases, you must use
    supplements/herbs/drugs. Diet and lifestyle alone
    are obviously inadequate.


    (Talking about nutritious food, I couldn't even boil a small
    packet of Maggi mee for lunch when my schizoid malicious
    younger brother locked the kitchen door and hid away the keys
    for two days just a few months ago.)

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